弓建华   肿瘤室   副研究员   硕士生导师

教育背景及工作经历：

2004年毕业于山西医科大学，获生理学硕士学位。2007年毕业于北京协和医学院，获微生物与生化药学博士学位。现就职于医药生物技术研究所肿瘤室，从事抗肿瘤药物研究工作。2012 -2014期间年赴美国犹他州立大学从事转基因大动物肿瘤模型及肿瘤代谢相关研究。

主要研究方向：肿瘤免疫治疗药物研究；基于靶点发现的新型小分子抗肿瘤药物；抗体药物

专业研究领域：抗肿瘤药物

代表性论文：

1. M. Zhang, H. Cai, Y. Du, Y. Wang, J. Gong#, J. Xu#, X. Liu#, Enhancing the Therapeutic Efficacy of Gefitinib in Human Non-Small-Cell Lung Cancer through Drug Combination, Mol Pharm, 18 (2021) 1397-1407.

2. J. Liu, M. Zhang, Y. Kan, W. Wang, J. Liu, J. Gong#, J. Yang#, Nuclear Factor-κB Activating Protein Plays an Oncogenic Role in Neuroblastoma Tumorigenesis and Recurrence Through the Phosphatidylinositol 3-Kinase/Protein Kinase B Signaling Pathway, Frontiers in Cell and Developmental Biology, 8 (2021).

3. J. Gong, F. Guo, W. Cheng, H. Fan, Q. Miao, J. Yang, Preliminary biological evaluation of 123I-labelled anti-CD30-LDM in CD30-positive lymphomas murine models, Artif Cells Nanomed Biotechnol, 48 (2020) 408-414.

4. J.H. Gong, Y.B. Zheng, M.R. Zhang, Y.X. Wang, S.Q. Yang, R.H. Wang, Q.F. Miao, X.J. Liu, Y.S. Zhen, Dexamethasone enhances the antitumor efficacy of Gemcitabine by glucocorticoid receptor signaling, Cancer Biol Ther, 21 (2020) 332-343.

5. X. Zhao, X. Qi, W. Lian, X. Tong, H. Wang, L. Su, P. Wei, Z. Zhuang, J. Gong#, L. Bai#, Trichomicin Suppresses Colorectal Cancer via Comprehensive Regulation of IL-6 and TNFalpha in Tumor Cells, TAMs, and CAFs, Front Pharmacol, 11 (2020) 386.

6. Y.B. Zheng#, J.H. Gong#, Y.S. Zhen, Focal adhesion kinase is activated by microtubule-depolymerizing agents and regulates membrane blebbing in human endothelial cells, J Cell Mol Med, 24 (2020) 7228-7238.

7. R. Wang, L. Li, A. Duan, Y. Li, X. Liu, Q. Miao#, J. Gong#, Y. Zhen, Crizotinib enhances anti-CD30-LDM induced antitumor efficacy in NPM-ALK positive anaplastic large cell lymphoma, Cancer Lett, (2019).

8. J. Yang, F. Guo, L. Yuan, G. Lv, J. Gong#, J. Chen#, Elevated expression of the V-ATPase D2 subunit triggers increased energy metabolite levels in Kras(G12D) -driven cancer cells, J Cell Biochem, (2019).

9. C. Zhang, L.Y. Guo, D. Mu, J.H. Gong#, J. Chen#, Induction of apoptosis and erythroid differentiation of human chronic myelogenous leukemia K562 cells by low concentrations of lidamycin, Oncol Rep, 41 (2019) 475-482.

10. J. Gong, Y. Zheng, Y. Wang, W. Sheng, Y. Li, X. Liu, S. Si, R. Shao, Y. Zhen, A new compound of thiophenylated pyridazinone IMB5043 showing potent antitumor efficacy through ATM-Chk2 pathway, PLoS One, 13 (2018) e0191984.

专利：

1. 硝基苯甲酸类化合物在制备治疗肿瘤的药物中的应用. 郑艳波，弓建华，甄永苏，刘秀均，李毅，司书毅. 专利号：CN111297870 B (授权)

2. 一种治疗肿瘤的复合物及其制剂和用途. 弓建华，郑艳波，刘秀均，甄永苏，李毅. 申请号：2020102130166, 申请日：2020.03.24.（申请）

3. 一种哒嗪酮类化合物在肿瘤治疗中的应用. 弓建华;郑艳波;甄永苏;李毅;刘秀均;司书毅.专利号：201710429186 （授权）

联系电话：18514647566

电子邮箱： ann_gong@imb.pumc.edu.cn