张涛   菌种保藏室   副研究员   硕士生导师

教育背景及工作经历：

2019/09 – 至今 中国医学科学院医药生物技术研究所 副研究员

2017/10-2019/09 中国医学科学院医药生物技术研究所 助理研究员

2015/04-2017/09 中国医学科学院药物研究所 博士后

2012/12-2014/12 美国纽约州卫生署沃兹沃斯研究中心 博士后

2006/09-2012/07 中国科学院微生物研究所 博士

主要研究方向：丝状真菌天然药物分子生物合成与代谢工程

专业研究领域：1、通过交叉学科研究手段，包括分子遗传、结构生物学、生物化学与天然产物化学，解析丝状真菌中结构独特的化合物生物合成途径和酶学机制，鉴定特殊/新颖功能生物酶。2、针对特殊生境微生物（极地真菌、植物内生真菌），利用基因挖掘策略，通过表观遗传/靶向操纵途径调控因子，从而激活沉默基因簇，发现常规实验条件下难以合成的新结构活性化合物。

代表性论文：

1. Ren P, Rajkumar SS, Zhang T, Sui H, Masters PS, Martinkova N, Kubátová A, Pikula J, Chaturvedi S, Chaturvedi V. A common partitivirus infection in United States and Czech Republic isolates of bat white-nose syndrome fungal pathogen Pseudogymnoascus destructans.Sci Rep. 2020,10(1):13893.

2. Zhang T, Ren P, De Jesus M, Chaturvedi V, Chaturvedi S. Green Fluorescent Protein Expression in Pseudogymnoascus destructans to Study Its Abiotic and Biotic Lifestyles. Mycopathologia,2018,183(5):805-814.

3. Gao SS#, Zhang T#, Garcia-Borràs M, Hung YS, Billingsley JM, Houk KN, Hu Y, Tang Y. Biosynthesis of heptacyclic duclauxins requires extensive redox modifications of the phenalenone aromatic polyketide.J Am Chem Soc, 2018,140(22):6991-6997.（#co-fisrt author）

4. Zhang T#, Wan J#, Zhan Z, Bai J, Liu B, Hu Y. Activation of an unconventional meroterpenoid gene cluster in Neosartorya glabra leads to the production of new berkeleyacetals.Acta Pharmaceutica Sinica B,2018,8(3):478-487.（#co-fisrt author）

5.Zhang F, Liu H,Zhang T, Pijning T, Yu L, Zhang W, Liu W, Meng X.Biochemical and genetic characterization of fungal proline hydroxylase in echinocandin biosynthesis. Appl Microbiol Biotechnol. 2018,102(18):7877-7890.

6.Bai J#, Yan D#, Zhang T, Guo Y, Liu Y, Zou Y, Tang M, Liu B, Wu Q, Yu S, Tang Y, Hu Y. A Cascade of Redox Reactions Generates Complexity in the Biosynthesis of the Protein Phosphatase-2 Inhibitor Rubratoxin A. Angew Chem Int Ed Engl. 2017,56(17):4782-4786.  

7. Zhang T, Ren P, Chaturvedi V, Chaturvedi S. Novel Trichoderma polysporum strain for the biocontrol of Pseudogymnoascus destructans, the fungal etiologic agent of bat White Nose Syndrome.PLoS One, 2015,10(10):e0141316.

8. Zhang T, Ren P, Chaturvedi V, Chaturvedi S. Development of an Agrobacterium-mediated transformation system for the cold-adapted fungi Pseudogymnoascus destructans and P. pannorum.Fungal Genet Biol,2015,81:73-81.

9. Zhang T#, Victor TR#, Rajkumar SS, Li X, Okoniewski JC, Hicks AC, Davis AD, Broussard K, LaDeau SL, Chaturvedi S, Chaturvedi V. Mycobiome of the bat white nose syndrome affected caves and mines reveals diversity of fungi and local adaptation by the fungal pathogen Pseudogymnoascus (Geomyces) destructans. PLoS One. 2014,9(9):e108714.（#co-fisrt author）

10. Zhuo Y#, Zhang T#, Wang Q, Cruz-Morales P, Zhang B, Liu M, Barona-Gómez F, Zhang L. Synthetic biology of avermectin for production improvement and structure diversification. Biotechnol J. 2014,9(3):316-25.（#co-fisrt author）

11. Zhang T#, Zhuo Y#, Jia X, Liu J, Gao H, Song F, Liu M, Zhang L. Cloning and characterization of the gene cluster required for beauvericin biosynthesis in Fusarium proliferatum. Sci China Life Sci. 2013,56(7):628-37.（#co-fisrt author）

12. Zhang T, Jia X, Zhuo Y, Liu M, Gao H, Liu J, Zhang L. Cloning and characterization of a novel 2-ketoisovalerate reductase from the beauvericin producer Fusarium proliferatum LF061. BMC Biotechnol. 2012,12:55.

专利：张立新，张涛，刘金涛，贾晓鹏。白僵菌素合成相关蛋白质系统及其编码基因簇与应用。授权号：ZL201110322036.8

联系电话：010-63017304

电子邮箱：tzhang@imb.cams.cn