王玉成   有机化学室   制剂室主任   教授   博士生导师

教育背景及工作经历：

1983.9-1988.7 上海医科大学 药学院 药物化学专业学习

1988.7-1991.7 中国协和医科大学 医药生物技术研究所 攻读硕士学位

1991.8-1997.8 江苏徐州第三制药厂 研究所副所长

1997.9-2001.8 江苏徐州师范大学 化学系教研室主任

2001.9-2004.5 中国协和医科大学 医药生物技术研究所 攻读博士学位

2004.6-至今 中国医学科学院 医药生物技术研究所工作

主要研究方向：药物化学

专业研究领域：抗感染、抗肿瘤和代谢综合症药物的设计、合成、先导物的发现以及构效关系研究。

代表性论文：

1、Minghua Wang1, Guoning Zhang1, Jianyuan Zhao1, Ningning Cheng, Yujia Wang, Yuanhui Fu, Yanpeng Zheng, Juxian Wang, Mei Zhu, Shan Cen*, Jinsheng He**, Yucheng Wang*. Synthesis and antiviral activity of a series of novel quinoline derivatives as anti-RSV or anti-IAV agents. Eur. J. Med. Chem., 2021, 113208. Doi: 10.1016/j.ejmech.2021.113208

2、Guoning Zhang 1, Minghua Wang 1, Jianyuan Zhao 1, Yujia Wang, Mei Zhu, Juxian Wang**, Shan Cen***, Yucheng Wang*. Design, synthesis and in vitro anti-influenza A virus evaluation of novel quinazoline derivatives containing S-acetamide and NHacetamide moieties at C-4. Eur. J. Med. Chem., 2020, 206: 112706.

3、Mei Zhu, Ling Ma, Huiyu Zhou, Biao Dong, Yujia Wang, Zhen Wang, Jinming Zhou, Guoning Zhang, Juxian Wang, Chen Liang, Shan Cen**, Yucheng Wang*. Preliminary SAR and biological evaluation of potent HIV-1 protease inhibitors with pyrimidine bases as novel P2 ligands to enhance activity against DRV-resistant HIV-1 variants. Eur. J. Med. Chem., 2020, 185: 111866.

4、Mei Zhu1, Ling Ma1, Jiajia Wen, Biao Dong, Yujia Wang, Zhen Wang, Jinming Zhou, Guoning Zhang, Juxian Wang, Ying Guo, Chen Liang, Shan Cen **, Yucheng Wang *. Rational design and Structure_Activity relationship of coumarin derivatives effective on HIV-1 protease and partially on HIV-1 reverse transcriptase. Eur. J. Med. Chem., Eur. J. Med. Chem, 2020, 186: 111900.

5、Guo-Ning Zhang 1, Qiang Li 1, Jianyuan Zhao, Xuandi Zhang, Zhuxin Xu, Yujia Wang, Yuanhui Fu, Qi Shan, Yanpeng Zheng, Juxian Wang, Mei Zhu, Ziqiang Li, Shan Cen **, Jinsheng He ***, Yucheng Wang *. Design and synthesis of 2-((1H-indol-3-yl)thio)-N-phenyl-acetamides as novel dual inhibitors of respiratory syncytial virus and influenza virus A. Eur. J. Med. Chem., 2020, 186: 111861.

专利：

1、一种胆酸类衍生物及其制备方法和应用CN110804082B

2、RT/PR双靶点HIV抑制剂及其制备方法和应用CN108409698B

3、异羟肟酸类衍生物、制备方法和应用CN111233730A

4、一种酰胺类衍生物或其药学上可接受的盐及其制备方法和应用CN108558808B

5、一种胆酸类衍生物及其制备方法和应用CN110804082A

联系电话：01063165263

电子邮箱：wangyucheng@imb.pumc.edu.cn