张德武   菌种保藏研究室   研究员   博士生导师

教育背景及工作经历：

2024/09至今        中国医学科学院医药生物技术研究所 研究员

2016/07-2024/08 中国医学科学院医药生物技术研究所 副研究员

2013/09-2016/07 中国医学科学院医药生物技术研究所 助理研究员

2010/09-2013/07 北京协和医学院药物研究所 理学博士

主要研究方向：微生物天然产物化学及其合成生物学研究

专业研究领域：重点关注真菌和放线菌来源的活性次级代谢产物及其合成生物学研究。主要包括：1利用基因组挖掘和分析技术从特殊生境（植物内生、地衣、沙漠、高原、南北极、海洋等）微生物中快速发现结构新颖的活性天然产物；2、新颖活性天然产物的合成生物学改造、生物合成途径解析及相关酶功能鉴定。3、利用微生物转化、化学半合成、体外酶催化等技术快速制备药物先导物。近年主持了国家自然科学基金、北京市自然科学基金等多项课题的研究。在国内外学术期刊发表研究论文70余篇，以第一作者/通迅作者（含共同）在Acta Pharm Sin B、Org Lett等期刊发表论文近40篇。参与申请专利10余项。

代表性论文：

1. Du Qingrong#, Chen Ming#, Liu Yu, Ma Ling, Bai Jinglin, Hu Jun, Zhang Tao, Cen Shan, Wang Fang*, Yu Liyan*, Zhang Dewu*. Aspversols A-H, monomeric and dimeric phenolic bisabolene sesquiterpenoids with antiviral and cytotoxic activities from polar moss-derived fungus Aspergillus sp. CPCC 401664. Phytochemistry 2025, 236: 114515.

2. Guo Zhe#, Zhang Dewu#*, Wang Yujia, Bai Jinglin, Hu Jun, Cen Shan, Yu Liyan*. An antiviral oligomerized linear thiopeptide with a nitrile group from soil-derived Streptomyces sp. CPCC 203702. RSC Adv. 2024, 14: 8260-8263.

3. Zhang Tao#, Gu Guowei#, Liu Guodong, Su Jinhua, Zhan Zhilai, Zhao Jianyuan, Qian Jinxiu, Cai Guowei, Cen Shan, Zhang Dewu*, Yu Liyan*. Late-stage cascade of oxidation reactions during the biosynthesis of oxalicine B in Penicillium oxalicum. Acta Pharm. Sin. B 2023, 13: 256-270.

4. Gu Guowei, Zhang Tao, Zhao Jianyuan, Zhao Wuli, Tang Yan, Wang Lu, Cen Shan, Yu Liyan*, Zhang Dewu*. New dimeric chromanone derivatives from the mutant strains of Penicillium oxalicum and their bioactivities. RSC Adv. 2022, 12: 22377-22384.

5. Zhang Dewu*, Wang Yujia, Hu Xinxin, Wang Xiaoyu, Li Linzi, Gu Guowei, Zhang Bingyuan, Cen Shan, You Xuefu, Yu Liyan*. Cyclic and linear thiopeptides from soil-derived Streptomyces sp. CPCC 203702 with antiviral and antibacterial activities. Chin. J. Chem. 2021, 39: 3277-3284.

6. Zhang Dewu, Tao Xiaoyu, Gu Guowei, Wang Yujia, Zhao Wenxia, Zhao Wuli, Ren Yan*, Dai Shengjun*, Yu Liyan*. Microbial transformation of neo-clerodane diterpenoid, scutebarbatine F, by Streptomyces sp. CPCC 205437. Front. Microbiol. 2021, 12: 62321.

7. Zhang Dewu, Gu Guowei, Zhang Bingyuan, Wang Yujia, Bai Jinglin, Fang Yuan, Zhang Tao, Dai Shengjun, Cen Shan, Yu Liyan.* New phenol and chromone derivatives from the endolichenic fungus Daldinia species and their antiviral activities. RSC Adv. 2021, 11: 22489-22494.

8. Tang Yan, Gu Guowei, Wang Jing, Guo Zhe, Zhang Tao, Cen Shan, Dai Shengjun, Yu Liyan*, Zhang Dewu*. Four new chromone derivatives from the Arctic fungus Phoma muscivora CPCC 401424 and their antiviral activities. J. Antibiot. 2023, 76: 88-92.

9. Su Cong, Tao Xiaoyu, Yin Zhen, Zhang Xiaolin, Tian Jinying, Chen Ridao, Liu Jimei, Li Li, Ye Fei, Zhang Peicheng, Zhang Dewu*, Dai Jujgui*. Morusalones A-D, Diels-Alder adducts with 6/7/6/6/6/6 hexacyclic ring systems as potential PTP1B inhibitors from cell culutres of Morus alba. Org. Lett. 2019, 21: 9463-9467.

10. 2. Fan Yijun^#, Zhang Dewu^#, Tao Xiaoyu, Wang Yuanhao, Liu Jimei, Li Li, Zhao Jianyuan, Yu Liyan, He Yupeng, Dai Jungui*, Tang Yefeng*. Biosynthetic hypothesis-guided discovery and total syntheses of PKS-NRPS hybrid metabolites from endophytic fungus Periconia species. Org. Lett. 2019, 21: 1794-1798.

授权专利：

1. 张德武，余利岩，岑山，督庆荣，郭哲，王宇佳，胡君，张涛，苏静，刘雨．一株青霉菌以及从其发酵产物中分离的化合物和用途．ZL 202410349131.4

2. 张德武，余利岩，郭哲，王静，刘雨，岑山，胡君，梁云毅，何文妮，张涛，王昭阳．Leporin类化合物及其制备方法和在制备抗流感病毒药物中的用途．CN 202510235096.8

3. 余利岩，张涛，张德武，谷国威，苏静．化合物oxalicine B生物合成基因簇和C-15羟基化酶OxaL以及应用．ZL 202111627219.0

荣誉奖励：曾获山东省科学技术奖、中国药学大会优秀论文二等奖、北京协和医学院院校优秀博士学位论文提名等多项奖励。

学术任职：中国菌物学会药用真菌专业委员会委员、教育部学位与研究生教育通讯评议专家、Front Microbiol副主编、Mini-Rev Org Chem编委，Lett Org Chem编委、Chin J Nat Med青年编委、Eng Microbiol青年编委、中国抗生素杂志青年编委。十余种SCI期刊审稿人。

联系电话：010-63017304

电子邮箱：zhangdewuever@163.com; zhangdewu@imb.pumc.edu.cn