韩莹 微生物代谢工程室 副研究员

教育背景及工作经历：

2022.10 –至今 中国医学科学院医药生物技术研究所 副研究员

2022.01–2022.09 中国医学科学院医药生物技术研究所 助理研究员

2016.09–2021.12 中国食品药品检定研究院 助理研究员

2014.10–2016.08 中国食品药品检定研究院 博士后

2011.08–2014.07 北京协和医学院 微生物与生化药学 博士

2008.08–2011.07 首都医科大学 卫生毒理学 硕士

2003.08–2007.07 大连医科大学 药学 学士

主要研究方向：药物毒理学、计算系统毒理学

专业研究领域：1. 药物毒性效应谱、毒效应靶器官、潜在靶基因/蛋白及毒作用机制。2. 化合物结构与毒性关系。3.疾病模型构建与化合物筛选。

代表性论文：

1. Xinyan Ma#, Ruixian Guo#, Huibo Xu, Yuanyuan Ma, Rui Zhang, Xinyan Liu, Jingpu Zhang*, Ying Han*, Developmental adcyap1b loss leads to hemorrhage, disrupted hemostasis, and a blood coagulation cascade in zebrafish, J Thromb Haemost. 2023, 1–14. https://doi.org/10.1016/j.jtha.2023.12.010

2. Ruixian Guo#, Xinyan Ma#, Huibo Xu, Yuanyuan Ma, Rui Zhang, Xinyan Liu, Binan Lu, Jingpu Zhang*, Ying Han*, In silico prediction and a systematic toxicology-based in vivo investigation uncovering the mechanism of aquatic toxicity caused by beta-lactam antibiotics, Chemosphere, 2024, 349: 140884.

3. Ying Han, Yuanyuan Ma, Junwei Tong, Jingpu Zhang*, Changqin Hu*, Systems assessment of statins hazard: Integrating in silico prediction, developmental toxicity profile and transcriptomics in zebrafish, Ecotoxicol. Environ. Saf., 2022, 243: 113981.

4. Ying Han, Yuanyuan Ma, Bo Chen, Jingpu Zhang*, Changqin Hu*, Hazard assessment of betalactams: Integrating in silico and QSTR approaches with in vivo zebrafish embryo toxicity testing, Ecotoxicol. Environ. Saf., 2022, 229: 113106.

5. Ying Han, Yuanyuan Ma, Shangchen Yao, Jingpu Zhang*, Changqin Hu*, In vivo and in silico evaluations of survival and cardiac developmental toxicity of quinolone antibiotics in zebrafish embryos (Danio rerio), Environ. Pollut., 2021, 227: 116779.

6. Rui xian Guo, Junping Lv, Huibo Xu, Yinghui Bai, Binan Lu*, Ying Han*, A systems toxicology approach to explore toxicological mechanisms of fluoroquinolones-induced testis injury, Ecotoxicol. Environ. Saf., 2021, 228: 113002.

7. Ying Han, Jingpu Zhang*, Chang Qin Hu*, Xia Zhang, Bufang Ma, Peipei Zhang, In silico ADME and toxicity prediction of ceftazidime and its impurities. Front. Pharmacol., 2019, 10: 434.

8. Ying Han, Jingpu Zhang*, Changqin Hu*, A systematic toxicity evaluation of cephalosporins via transcriptomics in zebrafish and in silico ADMET studies, Food Chem. Toxicol., 2018, 116: 264-271.

9. Ying Han, Bo Chen, Jingpu Zhang*, Changqin Hu*, Cardiac safety evaluation in zebrafish and in silico ADME prediction of cephalosporins with an aminothiazoyl ring at the C-7 position, Toxicol. Appl. Pharmacol., 2018, 347: 33–44.

10. Ying Han, Jianqin Qian, Jingpu Zhang*, Changqin Hu*, ChenWang, Structure-toxicity relationship of cefoperazone and its impurities to developing zebrafish by transcriptome and Raman analysis, Toxicol. Appl. Pharmacol., 2017, 327: 39–51.

专利：

1. 韩莹，张靖溥，国瑞贤，马媛媛，陈博，张苗青，刘馨妍，张锐。一种sgRNA组合及其应用、斑马鱼Adcyap1b基因突变体模型及其构建方法，中国，申请号202310221769.5

2. 韩莹，马媛媛，张靖溥，马鑫彦，张锐，杜纪阳，刘可慧，刘馨妍。突变体斑马鱼在制备凝血功能障碍疾病的动物模型中的应用，中国，申请号202311609786.2

3. 韩莹，张靖溥，杜纪阳，刘可慧，马媛媛，张锐，马鑫彦。一种sgRNA组合及其应用,中国,申请号202311615919.7

4. 马媛媛，张靖溥，韩莹，陈博，张苗青，张锐，刘馨妍。一种敲除斑马鱼ddx18基因的sgRNA组合及其应用中国，申请号202310222452.3

联系电话：010-63186645

电子邮箱：hy_0310001@163.com; hanying@imb.pumc.edu.cn