王璐璐 病毒室 研究员  博士生导师

教育背景及工作经历：

1992-09 至 1996-06 复旦大学上海医学院 理学士

2000-09 至 2003-06 北京协和医学院 理学硕士

2014-09 至 2018-01 北京协和医学院 医学博士

1996-08 至 1998-02 中国医学科学院医药生物技术研究所  研究实验员

1998-02 至 2022-02 中国医学科学院药物研究所制剂室  副研究员,研究员

2022-03 至 今   中国医学科学院医药生物技术研究所  研究员   北京协和医学院准聘助理教授

主要研究方向：

生物药剂学、小分子药物机制、新药研发

专业研究领域：

研究工作主要聚焦药物的转化性研究，并通过药理-药剂的结合促进新药研究的深度、创新性、及实用性。研究重点为组织微生物群靶向递送系统、肿瘤微环境靶向递送系统、天然产物药物智能递送系统研究，以及抗感染、抗代谢性疾病、抗肿瘤药物研发。

代表性论文：

1. Kaichao Song#, Yumei Hao#, Yi Liu, Ruifeng Cao, Xiuli Zhang, Shuwang He, Jin Wen, Wensheng Zheng*, Lulu Wang*, Yujia Zhang*. Preparation of pectin-chitosan hydrogels based on bioadhesive-design micelle to prompt bacterial infection wound healing. Carbohyd Polym 300 (2023) 120272. https://doi.org/10.1016/j.carbpol.2022.120272

2. Kaichao Song, Yumei Hao, Xiaochuan Tan, Hongdong Huang*, Lulu Wang*, Wensheng Zheng J Control Release. 356 (2023) 448–462. https://doi.org/10.1016/j.jconrel.2023.03.007

3. Jin-Jin Cui, Rui Li, Xiao-Lei Ma, Hao-Yang Yu, Zhi-Gang Luo, Peng Du, Ling Ren, Xiao Ding, Xiu-Ping Guo, Wen-Sheng Zheng, Jian-Dong Jiang,* Yongsheng Che,* and Lu-Lu Wang* Prebiotic-Based Nanoamorphous Atorvastatin Attenuates Nonalcoholic Fatty Liver Disease by Retrieving Gut and Liver Health. Small Struct. 2023, 2200312. DOI: 10.1002/sstr.202200312

4. Yumei Hao,# Kaichao Song,# Xiaochuan Tan,# Yujia Zhang*, Lulu Wang*, and Wensheng Zheng*. Reply to “Comment on ‘Reactive Oxygen Species-Responsive Polypeptide Drug Delivery System Targeted Activated Hepatic Stellate Cells to Ameliorate Liver Fibrosis’”ACS Nano. 2023, 17, 5, 4096-4097. DOI: 10.1021/acsnano.3c00848

5. He Li, Xiaochuan Tan, Yi Liu, Ya Meng, Yongguang Wang, Xiuli Zhang, Haihua Xiao, Yujia Zhang*, Lulu Wang*, Wensheng Zheng*, Hongdong Huang*. Ruxolitinib-loaded black phosphorus nanosheets actively target proximal tubule cells to ameliorate nephrotic syndrome by reducing inflammation and oxidative stress. Nano Today 47 (2022) 101631. https://doi.org/10.1016/j.nantod.2022.101631.

6. Ling Ren#, Xiao-Lei Ma#, Hong-Liang Wang#, Rui Li#, Jin-Jin Cui, Peng-Ju Yan, Ya-Nan Wang, Xiao-You Yu, Peng Du, Hao-Yang Yu, Hui-Hui Guo, Rou Tang, Yong-sheng Che, Wen-Sheng Zheng*, Jian-Dong Jiang*, Lu-Lu Wang*. Prebiotic-like cyclodextrin assisted silybin on NAFLD through restoring liver and gut homeostasis. J Control Release. 348 (2022) 825–840. https://doi.org/10.1016/j.jconrel.2022.06.031

7 Xiao-Lin Li#, Jin-Jin Cui#, Wen-Sheng Zheng#, Jin-Lan Zhang#, Rui Li, Xiao-Lei Ma, Miao Lin, Hui-Hui Guo, Cong Li, Xiao-You Yu, Peng Du, Li-Min Zhao, Shuwang He, Pei Lan, Jian-Dong Jiang,* Yongsheng Che,* and Lu-Lu Wang*. Bicyclol Alleviates Atherosclerosis by Manipulating Gut Microbiota. Small. 2022, 2105021. DOI: 10.1002/smll.202105021

8. Jin-Lan Zhang^#, Yu-Huan Li#, Lu-Lu Wang^#, Hong-Qi Liu^#, Shuai-Yao Lu^#, Yong Liu, Ke Li, Bin Liu, Su-Yun Li, Feng-Min Shao, Kun Wang, Ning Sheng, Rui Li, Jin-Jin Cui, Pei-Chun Sun, Chun-Xia Ma, Bo Zhu, Zhe Wang, Yuan-Hao Wan, Shi-Shan Yu, Yongsheng Che, Chao-Yang Wang, Chen Wang, Qiangqian Zhang, Li-Min Zhao, Xiao-Zhong Peng*, Zhenshun Cheng*, Jun-Biao Chang*，Jian-Dong Jiang*. Azvudine is a thymus-homing anti-SARS-CoV-2 drug effective in treating COVID-19 patients. Signal Transduct Tar. (2021) 6:414

9. Rou Tang, Rui Li, He Li, Xiao-Lei Ma, Peng Du, Xiao-You Yu, Ling Ren, Lu-Lu Wang* and Wen-Sheng Zheng*. Design of Hepatic Targeted Drug Delivery Systems for Natural Products: Insights into Nomenclature Revision of Nonalcoholic Fatty Liver Disease. ACS Nano. 2021, 15, 17016−17046 https://doi.org/10.1021/acsnano.1c02158

10. Xiaolei Ma#, Tingting Zhang#, Zhigang Luo, Xiaolin Li, Miao Lin, Rui Li, Peng Du, Xiaoyou Yu, Chen Ma, Pengju Yan, Jin Su, Lulu Wang*, Yuhuan Li*, Jiandong Jiang. Functional nano-vector boost antiatherosclerosis efficacy of berberine in Apoe(/) mice. Acta Pharm Sin B. 2020;10(9):1769e1783. https://doi.org/10.1016/j.apsb.2020.03.005

11. Hui-Hui Guo^#, Chen-Lin Feng^#, Wen-Xuan Zhang^#, Zhi-Gang Luo^#, Hong-Juan Zhang, Ting-Ting Zhang, Chen-Ma, Yun Zhan, Rui Li, Song Wu, Zeper Abliz, Cong Li, Xiao-Lin Li, Xiao-Lei Ma, Lu-Lu Wang*, Wen-Sheng Zheng*, Yan-Xing Han, Jian-Dong Jiang*. Liver-target nanotechnology facilitates berberine to ameliorate cardio-metabolic diseases Nat Commun. 2019,10 (1):1981-1996. https://doi.org/10.org/10.1038/s41467-019-09852-0

12 Hui-Hui Guo ^#, Chen Ma ^#, Wen-Sheng Zheng ^#, Yang Luo ^#, Cong Li, Xiao-Lin Li, Xiao-Lei Ma, Chen-Lin Feng, Ting-Ting Zhang, Yan-Xing Han, Zhi-Gang Luo, Yun Zhan, Rui Li, Lu-Lu Wang*, Jian-Dong Jiang(*). Dual-Stimuli-Responsive Gut Microbiota-Targeting Berberine-CS/PT-NPs Improved Metabolic Status in Obese Hamsters Adv Funct Mater. 2019, 29 (14): 1808197. DOI: 10.1002/adfm.201808197

授权专利：

1. 林艳和，蒋建东，王璐璐。含有灯盏细辛提取物的口服制剂及其制备方法。专利号：202111612015.X。

2. 王璐璐，郑稳 生，陈少华， 相莉，张秀立，张宇佳， 魏曼，张楠。一种具有生物粘附性的氟尿嘧啶直肠用温度敏感性乳剂及其制备方法。专利号：ZL 2016 1 1184979.8。

3. 郑稳生，谭晓 川，张宇佳， 王璐璐。经皮吸收的妥洛特罗控释贴剂及其制备方法。专利号：ZL 2016 1 1184979.8。

4. 林艳和，蒋建东，王璐璐。含有咖啡酸酯盐和灯盏花素盐的口服制剂及其制备方法。专利号：202111612034.2。

学术任职：中国药学会工业药剂学专业委会委员，秘书

联系电话：13621284066

电子邮箱：wanglulu@imb.cams.cn