Structural revision and absolute configuration of burnettramic acid A
Org Lett
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时间:2021-08-22
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论文题目: Structural revision and absolute configuration of burnettramic acid A
作者:Jiao Li,Minghua Chen, Xiaomeng Hao, Shasha Li, Fang Li, Liyan Yu, Chunling Xiao, Maoluo Gan
期刊名称:Org Lett
IF:6.091
年份:2020
卷期页:22(1):98-101
The recently discovered antibiotic burnettramic acid A (1) and three new congeners, burnettramic acids C-E (2-4), were identified from the co-cultures of two marine Aspergillus strains. The structure of burnettramic acid A was revised on the basis of reinterpretation of the nuclear magnetic resonance (NMR) data and chemical derivatization. The full absolute configurations of burnettramic acids were established using the Mosher ester method and Marfey's analysis, combined with density functional theory calculation of NMR and electric circular dichroism data.