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Zelkovamycins B–E, Cyclic Octapeptides Containing Rare Amino Acid Residues from an Endophytic Kitasatospora sp

Org Lett

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时间:2021-08-22    

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论文题目: Zelkovamycins B–E, Cyclic Octapeptides Containing Rare Amino Acid Residues from an Endophytic Kitasatospora sp

作者:Xiaomeng Hao, Jiaqing Yu, Yujia Wang, Jack A. Connolly, Yufeng Liu, Yuqin Zhang, Liyan Yu, Shan Cen*, Rebecca J. M. Goss,* Maoluo Gan*

期刊名称:Org Lett

IF6.091

年份:2020

卷期页:22(23): 9346–9350

Four unusual cyclopeptides, zelkovamycins B-E (1-4), were isolated from an endophytic Kitasatospora sp. Zelkovamycin B was featured by an unprecedented 3-methyl-5-hydroxypyrrolidine-2,4-dione ring system linked to the cyclopeptide skeleton. Their structures and full configurations were established by spectroscopic analysis, Marfey's method, and NMR calculations. A plausible biosynthetic pathway for zelkovamycins was proposed based on gene cluster analysis. Zelkovamycin E displayed potent inhibitory activity against H1N1 influenza A virus.